通过代谢视角与客户合作，我发现许多人对乳制品的耐受性不佳。，我想讨论一个主要原因——乳制品中的阿片肽类物质，即酪啡肽（casomorphins）。首先，我会分享客户和参与我计划的人群中与酪啡肽相关的主要症状；接着，我会解释什么是酪啡肽；然后，讨论它们对身体的影响；最后，介绍如何在对酪啡肽敏感的情况下，仍然合理摄入乳制品，同时避免其负面效应。

在进入正题之前，我先声明，我并不认为乳制品是糟糕的食物。如果能耐受乳制品，那是非常优质的食物，富含维生素、矿物质、蛋白质，且脂肪酸构成良好。然而，因为许多人在探索生能或代谢健康领域时，对乳制品感到困扰。我希望为这些人提供背景和细致分析，帮助他们理解为何无法耐受乳制品，并给出应对方法。这不是抨击乳制品，而是为那些对乳制品有问题的人提供更细致的视角。我自己和许多客户都曾因乳制品出现问题。

首先，我通常观察到哪些症状与乳制品耐受不良或酪啡肽反应相关？第一类是组胺反应，如皮疹、荨麻疹等。第二类是便秘，肠道蠕动减慢。第三类是肠道刺激，可能导致相反的效果，如乳制品快速通过肠道（可能是乳糖不耐受，也可能是酪啡肽引起的刺激）。此外，还可能出现腹胀，既不伴便秘也不伴腹泻。我还常看到脑雾和缺乏动力。如果对酪啡肽不耐受，可能会影响男性睾酮等激素水平，进而改变性欲。这些是我常观察到并归因于酪啡肽及其类阿片效应的症状。

那么，酪啡肽到底是什么？参考一篇论文，标题为《一个小差异会带来大影响吗？牛β-酪蛋白A1和A2变体与人体健康更新》。论文中，研究者明确定义了酪啡肽：β-酪啡肽是一组由4至11个氨基酸组成的肽链，均以酪氨酸残基开头，这一残基对其阿片活性至关重要。简单来说，酪啡肽是乳制品中酪蛋白部分的肽类，是一些氨基酸链，具有类似吗啡或羟考酮的类阿片效应。它们通过与体内阿片受体相互作用，产生类似效应。常见的酪啡肽包括β-酪啡肽4至β-酪啡肽11，其中β-酪啡肽7（BCM7）是研究最多的。

这引出了A1和A2乳制品的讨论。通常认为A2乳制品不会引发与A1乳制品相同的问题，这与β-酪啡肽有关。研究证实了这一点，我在客户中也发现，无法耐受A1乳制品的人可能能耐受A2乳制品。论文指出，β-酪啡肽7通过胃肠道蛋白水解消化，从β-酪蛋白A1和B中释放，但A2不会释放。这是由于β-酪蛋白基因在第67位单核苷酸多态性（SNP67）导致的氨基酸差异：A1变体中，脯氨酸被组氨酸替代。这种氨基酸替换改变了蛋白质二级结构的构象，影响酪蛋白胶束的物理特性。此外，A2变体中脯氨酸与异亮氨酸之间的肽键比A1变体中组氨酸与异亮氨酸之间的肽键更耐酶解。因此，A1 β-酪蛋白更容易水解，释放β-酪啡肽7。

具体来说，酪蛋白是由氨基酸链构成的。A2 β-酪蛋白和A1 β-酪蛋白在第67位氨基酸不同：A2为脯氨酸，A1为组氨酸。脯氨酸能阻挡消化酶的作用，而组氨酸允许消化酶切割，释放β-酪啡肽7。一旦从酪蛋白结构中释放，这种肽类就能对身体产生影响。

酪啡肽存在于哪些乳制品中？是否在酸奶、奶酪中也有？数量是否足以产生影响？论文指出，β-酪啡肽及其前体已在牛奶及多种乳制品中被检测到。对新鲜牛奶和经消化酶水解的牛奶进行定量检测发现，A1牛奶水解后β-酪啡肽7含量比A2牛奶高四倍；非水解牛奶中仅检测到微量β-酪啡肽7。研究还发现，A2 β-酪蛋白消化后也可能释放少量β-酪啡肽7。另一研究发现，A1/A1变体的β-酪蛋白经酶解后，β-酪啡肽7含量比A1/A2变体高3.2倍，而A2/A2变体未释放β-酪啡肽7。

奶牛的基因决定了酪蛋白类型：A2/A2（纯合）奶牛的牛奶不释放β-酪啡肽7；A1/A2（杂合）释放少量；A1/A1（纯合）释放较多。这与A1变体在第67位有组氨酸、A2有脯氨酸有关。

奶酪和酸奶是否含有酪啡肽？研究发现，β-酪啡肽9和10的前体存在于Gouda、Swiss、Blue、Limburger和Brie奶酪中，但未在成熟Cheddar奶酪中检测到，可能是因为成熟过程中降解。某些奶酪在发酵和熟化过程中，细菌或酶可能降解β-酪啡肽7。研究还发现，Gorgonzola、Fontina、Cheddar、Edam、Castel、Roquefort和Brie等奶酪中含有β-酪啡肽7，但熟化时间较长的奶酪（如荷兰式半硬奶酪）含量较低，短期熟化的软奶酪（如霉菌奶酪和法式奶酪）含量较高。

一些客户发现，即使是A2牛奶也无法耐受。研究显示，A2牛奶可能释放少量β-酪啡肽7，但可能是A1/A2杂合奶牛的奶源，而非A2/A2纯合。研究还确认，健康人类摄入牛奶或酪蛋白后，小肠中可检测到β-酪啡肽7，其含量足以引发生物效应。

酪啡肽对身体的影响是什么？β-酪啡肽7（最受研究的）通过激活μ阿片受体，影响内分泌、神经和免疫系统，导致镇痛、镇静、血压降低、恶心、呼吸减慢和肠道蠕动减少。以250克（8盎司）牛奶为例，含2-3克β-酪蛋白，消化后释放β-酪啡肽7，与μ阿片受体结合，影响心脏、骨骼、脑和肠道。

研究显示，β-酪啡肽7可能与缺血性心脏病死亡率升高相关（流行病学和动物研究，未完全证实）；可能降低成骨活性，增加髋部骨折风险；在脑部，可能增加高脂饮食偏好，促使肥胖；在肠道和免疫系统，减少细胞因子吸收，增加TH2免疫途径的炎症标志物（如IgG、白细胞渗透、谷胱甘肽、IL-4、组胺、髓过氧化物酶、单核细胞趋化蛋白）。还能诱导镇静，干扰多巴胺平衡，升高催乳素，抑制性激素生成。

许多人以为自己乳糖不耐受，实际上可能是对β-酪啡肽7的反应。研究表明，A1 β-酪蛋白衍生的β-酪啡肽7可能是乳糖不耐受综合征的重要因素。动物实验和人体试验显示，A1 β-酪蛋白摄入可能引发肠道炎症和消化不适，甚至在健康儿童中诱发类过敏性皮肤反应。

在学龄前儿童中，短期摄入常规牛奶（A1酪蛋白）显著增加TH2免疫相关的促炎症标志物和血清β-酪啡肽7水平，而A2牛奶未显示显著变化。排除A1牛奶可能缓解乳糖不耐受儿童的胃肠道症状。

β-酪啡肽还能引发组胺反应。我在尝试生能饮食时，重新引入牛奶后出现皮疹和荨麻疹。我对酪蛋白非常敏感，研究表明β-酪啡肽7可诱导免疫细胞释放组胺，引发类过敏反应，如皮肤红肿。

β-酪啡肽还可能影响认知功能。类似药理阿片类物质，食品来源的外啡肽（如β-酪啡肽7）可能穿过血脑屏障，结合运输蛋白，进入中枢神经系统，激活μ阿片受体。这可能导致脑雾、动力缺乏和性欲改变。我和许多客户在高乳制品饮食后出现这些症状，排除乳制品后症状改善。

如何管理β-酪啡肽的影响？是否必须完全避免乳制品？我的观点是存在一个谱系，不必全有或全无。第一步是改用A2乳制品，如A2奶牛奶、羊奶、山羊奶或水牛奶，这些动物的酪蛋白通常为A2型，β-酪啡肽不易释放，因第67位氨基酸为脯氨酸。

如果A2乳制品仍不耐受，尝试长时间发酵的A2奶酪，如陈年Gouda、Parmesan、Pecorino Romano、sharp Cheddar或Manchego。这些奶酪在熟化过程中，细菌或酶可能降解阿片肽，减少症状。

此外，β-酪啡肽7的摄入量可能很重要。少量乳制品可能无大碍，客户通常能耐受少量发酵乳制品（如1-2盎司奶酪）。乳制品中的蛋白质、脂肪、钙、钾和其他肽类有益，若能耐受，应适量摄入。

如果所有酪蛋白（A1或A2、酸奶、奶酪）都引发问题，可选择乳脂肪（如奶油、黄油）和乳清蛋白。乳清部分不含酪啡肽，我能耐受乳清蛋白但不耐酪蛋白。乳脂肪中的酪蛋白含量低，较少引发症状。但需注意，若对乳制品中的激素敏感，乳脂肪可能仍需谨慎（详见我的其他视频）。

总之，酪啡肽是乳制品不耐受的一个主要原因，但通过选择A2乳制品、长时间发酵奶酪、控制摄入量或使用乳清和乳脂肪，可以在敏感情况下继续享受乳制品的好处。

---

https://youtu.be/cNQ6ttzA9H4

Edit:2025.04.28

in my experience working with clients

through a protabolic lens I found that

many people do not actually tolerate

dairy very well now in this video I want

to discuss one of the major reasons I

think people struggle with dairy and

that is the opiate peptides known as the

quesomorphins with this what I first

want to do is share with you the typical

symptoms I'm seeing with my clients and

people who are working my program who

have issues with quesomorphins then I

want to show you what quesomorphins are

and from there I want to talk about what

they can do to your body and how you can

incorporate dairy while avoiding the

effects of quesomorphins if you are

somebody who is sensitive to them now

before we jump in to the meat of this

video what I want to preface this video

with is that I don't think that dairy is

necessarily a terrible food i think that

if you tolerate dairy it's an excellent

food it's very rich in vitamins minerals

proteins has a great fatty acid profile

etc however I'm creating this content

around dairy because there's many people

who are jumping into the bio energetic

sphere the protabolic spheres and are

having difficulties with dairy and I

want to provide some context for these

people and some nuance to the dairy

conversation so that they can figure out

why they may not be tolerating the dairy

and what they can do about it so again

this isn't a video to trash dairy this

is provide nuance to people who are

struggling with dairy because I myself

and many of my clients have been people

who have not done very well with dairy

products first things first what are the

symptoms that I typically see with

people who are not tolerating dairy well

or I determined that the response is

largely related to quesomorphins the

first one is histamine reactions to

dairy so this is rashes this is hives

things like this the next one is

constipation a slowing of bowel transit

time from there there's intestinal

irritation so you can actually have kind

of an opposite effect where the the

dairy products will move through you

quickly now that could also be related

to lactose but it could be the

irritation and you can get bloating from

the dairy without having either

constipation or having uh diarrhea i

also tend to see brain fog and a lack of

motivation if you don't do well with

quesomorphins and the last thing I tend

to see is an effect on hormones like

testosterone in men and then a

subsequent change in libido so these are

big components that I tend to see and I

I usually tie them to a poor reaction to

quesomorphins uh and their opiate- like

effects on the body so with that what

actually are quesomorphins so we have a

paper here titled does a little

difference make a big difference boine

beta casein A1 and A2 variants and human

health and update and in this paper the

researchers tell us exactly what

quesomorphins are so they say beta

quesomorphins are a group of peptides

with a chain length of 4 to 11 amino

acids all starting with tyrrosine

residue which is critical to their

opioid activity so basically these these

quesomorphins are peptides found in the

casein fraction of milk and they are

just essentially chains of amino acids

and they have an opiate-like effect so

they have similar effects to things like

morphine or oxycodone so they mirror

some of those effects because they

interact with the opiate receptors in

the body and so we can see the different

quesomorphins here there's strings of

amino acids and you have beta

quesomorphine 4 to beta quesomorphine 11

with one of the most famous or prominent

one being betaomorphin 7 which much of

the research has focused on this leads

us to the question of A1 and A2 dairy

because typically it's said that A2

dairy doesn't actually lead to the same

problems of A1 dairy and it's around the

beta case of morphins and this is that

there's actually validity to this case

uh and I do find with clients that

people who don't do well with A1 dairy

may actually be able to tolerate A2

dairy and we'll talk about that with the

solutions but basically what we'll see

here is and from the same paper the

researchers say beta caseorphine 7 is

yielded by the successive

gastrointestinal proteolytic digestion

of beta casein A1 and B but not A2 by

the enzymes pepsin pancreatic elastase

and leucine amopeptidase so essentially

what we see is that beta casein A1 and B

so different this are different types of

casein they can release the beta

caseorphins whereas A2 tends not to

release the beta quesomorphins I'm going

to talk about why in just a second so

the researchers go on to say they say

the cause of this difference is due to a

single nucleotide polymorphism of the

beta casein gene at the SNP67 and

proline substitution by histadine in A1

of the beta casein molecule this amino

acid substitution results in the

confirmational difference in the

expressed protein secondary structure

which may exert an influence on the

physical properties of the respective

casein myels they say additionally the

peptide bond between proline and

isolucine and the A2 variant has a

higher enzyatic resistance than that

between histadine and isolucine in the

A1 variant therefore the A1 beta casein

is more readily hydrarolyed resulting in

the release of beta quesomorphine 7 so

what does all this mean basically this

is casein here this is the strings of

amino acids that come from casein and we

have A2 beta casein here and we have A1

beta casein here so what's the big

difference well at position 67 so this

is the 67th amino acid you can see in A2

beta casein proline is here whereas in

A1 betaine histadine is there and why is

that special well proline basically

blocks the digestive enzyme whereas if

histadine is here it allows the

digestive enzyme to actually get access

and release this peptide here we see

beta quesomorphine 7 and then that

peptide then is once it's free from the

casein's protein structure is then able

to exert its effects on the body now the

next thing is in what types of dairy

it's like so we know it's in A1 casein

but do we see this in yogurt and cheeses

and things like this and so and and also

is there enough to actually have an

effect so going from that same paper the

researchers go on to say they say

betaaseomorphins and their precursors

have been identified in milk and various

dairy products a quantitative

examination of the betaaseomorphin 7 in

the fresh and hydrayed by digestive

enzyme boine milk revealed that in

hydrayzeed A1 milk there was a four-fold

higher level of betaomorphin 7 than in

A2 milk whereas in non-hydrayed milk

traces of betaomorphin 7 were found

small amounts of beta caseorphine 7

after digestion of the A2 beta casein

were also detected by Darte Vasquez at

Al and Lambert's ed when the casein gets

into the digestive tract and the enzymes

start to break down the protein it

actually releases betaomorphine 7 and

when they take milk and they add

digestive enzymes to it they actually

find that betaaseomorphin 7 is released

significantly more four times more in A1

milk than in A2 milk the researchers go

on and they continue they say other

results were obtained by hack edal who

found a 3.2 times higher level of beta

quesomorphin 7 released from A1 A1

variance after enzyatic digestion in

comparison to A1 A2 variant of beta

casein and no beta caseorphin 7 after

the digestion of A2 A2 variant of the of

the beta casein the cattle can inherit

different inherit different genes so you

have A1 A1 A1 A2 and A2 A2 this is

basically telling us the type of casein

that is produced so when you have cattle

who have A2 A2 casein they're they have

the genes for A2 A2 casein right they

are homozygous for A2 what you find is

that their milk does not release

betaomorphin 7 but when you have cattle

who are A1 A2 so they're hetererozygous

for this gene they release some

betaaseomorphin 7 and then when you have

cattle who are homozygous for A1 A1 case

they actually release quite a bit more

betaomorphin 7 and again it's related to

the structure that I showed you here

earlier where the A1 variety the A1 beta

casein has a histadine at position 67

whereas an A2 beta casein it has a

proline and this affects how the

digestive enzymes are able to interact

with that protein next up the question

is can we find these in cheese and

yogurt and things like this and so the

researchers say precursors of

betaaseomorphins or betaaseomorphin 9

and betaomorphin 10 were also found in

Gouda Swiss blue limber and brie cheeses

but not in mature cheddar cheeses

perhaps due to the degradation during

the ripening process so this is actually

interesting because some people find a

lot of clients that I've worked with

said “Hey I can only have a problem with

cheese but that's mostly casein so

what's going on?” And essentially as

certain cheeses are ripened and aged

over time they actually degrade the

bacteria can degrade the beta caseorphin

7 and also the enzymes present in the

cheese and the aging process itself

beyond the bacteria present in the milk

or in in the culture may actually

degrade the peptides in and of itself

they go on to say other research has

reported the presence of beta

quesomorphin 7 in gorgonzola guda

fentina and cheddar adamsky guda casled

rockpole and brie uh kazakquat and

camping and brie cheeses so basically

there's multiple different types of

cheeses that still contain beta

quesomorphin 7 but typically the general

idea is that the more aged the cheese

the less likely that you may find these

peptides and the researchers will say

here many of these findings were

qualitative however based on the

available data it seems that short

ripening of soft cheeses so mold cheeses

and French type cheeses contain more

betaomorphin 7 than the Dutch type semih

hard cheeses that are riper for or

ripened for longer something else to

consider here is I have had some people

who don't actually do well with A2 uh A2

beta casein milks like the A2 milk

variety that you can find in the store

and so there is some research that shows

that there may be some release of beta

quesomorphine 7 however I would wonder

if that's from varieties of cows that

are A1 A2 so they're hetererozygous not

homozygous for a A2 A2 and the

researchers say the release of

betaomorphin 7 um from both A1 and A2

milk beta case was recently confirmed by

Lambs Adal but did not uh but not by

Hawk Edal who did not find betaomorphins

in the hydrayzeed A2 milk the presence

of beta quesomorphin 7 was also

identified in vivo in the jigunum of

healthy humans who ingested bovine milk

or casein although the authors did not

specify the parental protein variant

they estimated that the amount of beta

quesomorphine was sufficient to elicit a

biological action you may find it in A2

milk so if you don't tolerate A2 milk

it's potentially you are releasing some

of the beta quesomorphins although again

like the question is is the milk used in

that study homozygous A2 A2 or was there

A1 A2 present for the genes and then the

other thing that we see here is that the

beta caseamorphins can in fact make it

into circulation and they do find it in

the human digestive tract the question

is is it enough to have an effect um and

basically what the authors say here is

that yes the betaaseomorphins can indeed

have an effect so with that what are the

effects of the betaaseomorphins on the

body what can you expect so I gave you

the symptoms but do I have mechanisms to

actually support those symptoms and yes

of course I do so we're going to go

through the research here so they say

betaomorphine 7 this is the one that's

mostly researched is known to influence

the endocrine nervous and immune systems

by activating the mu opioid receptors

which leads to different effects such as

analesa sedation reduced blood pressure

nausea decreasing respiration and bowel

motility and we have a graphic here

where they show you have A1 A2 A1 and A1

varieties what happens is milk gets they

produce milk it gets broken down here

into casein and then that casein can get

broken down into beta casein so this is

for 250 gram so an 8 oz glass of milk

will provide roughly 2 to three grams of

beta caseins um now from there the beta

casein you have the betaomorphin 7 which

that peptide gets cleaved but by the

digestive enzymes and it interacts with

the mu opioid receptors and then it has

a variety of different effects and so

some of the effects they talk about they

they break it down from the heart bone

brain and gut and they say with the

heart there is some research associating

again this is associated epidemiologic

components there's some rat studies with

it too but it's not clearcut that

there's higher mortality rates from

eskeemic heart disease in association

with beta case morphin 7 but again this

is not this is still uh very young in

the research so I wouldn't say this

conclusive they say there's lower

osteoplastic activity higher risk of hip

fracture from the from the opioid

peptide in the brain they say there's an

increased preference for highfat diet

which drives obesity plus um there they

say that there's effects on the gut and

on the immune system so they say there's

reduced cyine uptake and then there's an

increase and this is the one that was

done in humans specifically increase in

a range of markers of intestinal

inflammation with an activation of the

TH2 pathway of the immune system and so

basically we see increased immune

response with and IGG increased

infiltration of luccoytes um and then

changes in glutathione concentrations to

the cell as well as changes in IL4

histamine myelop peroxidase and monocy

chemotactin protein as well so basically

what you're seeing is it can interact

with the immune system and it can also

interact with the opioid system which

can uh induce sedation it can also

affect dopamine balance because the

opioids have a a sort of antagonistic

relationship with dopamine which then

can rise prolactin and have a negative

impact on the the sex steroids because

prolactin controls to some extent LH and

FSH signaling um on the gonads which are

responsible for the production of sex

steroids so there's a variety of ways

that BCM7 if you're sensitive to it can

give you a a series of symptoms and so I

want to go into them specifically now so

the first thing is that a lot of people

who may think that they actually have

lactose intolerance may be having issues

with the betaomorphins inside the milk

from the paper they say palad suggests

that bovine betaominorphine 7 derived

from A1 beta casein could also be an

important contributor to milk

intolerance syndrome hacked edal and

barnetal confirmed that the consumption

of betaominorphin 5 and 7 induce an

inflammatory immune response in the guts

of mice and rats respectively moreover

human trials performed by Ho at all

suggest differences in gastrointestinal

responses in some adult humans consuming

milk containing A1 or A2 beta casein so

some people don't do well with the

quesomorphins and it can cause

intestinal in inflammation by itself

they go on to further say a study

conducted by Gianquinadel also supported

the thesis that A1 A1 and A1 A2 beta

casein consumption by subjects with

lactose intolerance was associated with

gastrointestinal inflammation and

negative postair digestive discomfort

symptoms pseudoallergic skin reactions

to opiate sequences of bovine casein and

healthy children were presented by

palett brood edal and sinska edal so

basically what you're seeing is in human

studies there's a negative response in

some people to beta caseorphins this is

why this is why I think some people I've

had some clients who have no problem

with A1 dairy they don't have any

symptoms from it at all and then I have

other people who A1 dairy and even A2

dairy is no bueno for them they can't

tolerate it at all and again we all come

from different backgrounds we all have a

little bit different physiology and I

think this adjusts our responses to some

of these different components so some

people may not tolerate the beta

quesomorphins and so we'll talk about

what you can do with that in just a few

minutes here the next thing that we see

is that the beta quesomorphins can

actually drive inflammation so from the

paper they say effects were observed in

preschoolers with mild to moderate milk

intolerance results contain measurements

including hemoglobin interlucan 4 IGG

IGG1 betaorphin 7 glutathione CRP and so

these are immune markers inflammatory

markers they say it was found that even

short-term consumption of conventional

milk significantly increased both

pro-inflammatory markers related to the

TH2 immune response and beta caseorphine

level levels in the serum and in the

case of A2 milk consumption all the

parameters showed no statistically

significant difference so in children

who don't tolerate milk when they had A1

casein they had an inflammatory response

whereas when they had the A2 beta casein

they did not have that response they say

based on the results the authors

concluded that the exclusion of A1 milk

from the diet may help alleviate adverse

gastrointestinal symptoms in lactose

intolerant children the next thing we

see and this is actually something I had

experienced myself is that the beta case

can trigger histamine responses so I

remember when I first started and

embarking on the the bioenergetic diet

or a pet inspired diet I started to

incorporate milk now it took me a little

while to get there because you know I

was coming from low carb and paleo and

all this type of stuff but when I

started to incorporate milk I started to

get weird rashes and hives for me I'm

very sensitive to beta quesomorphins so

I don't do very well with casein at all

and so the research is what they say

here they say it's suggested that beta

quesomorphins can induce pseudoallergic

reactions by histamine release released

from immune cells steepnik and Kurick

showed inductive effects on the mass

cells of rodents after pre-incubation

with betaism morphin 7 immediately and

dose dependent wheel and flare-like

reactions in the skin of healthy

children were observed after beta case

of morphin 7 intrammal injection

basically some people will develop

immune reaction or potentially could

develop immune reaction to this peptide

and again I don't think it's everyone

because I have some clients no problem

with it but I've also for myself like

when I was doing quite a bit of dairy

maybe it was the betaomorphin 7

triggering this histamine release for me

maybe it was things going on with

inflammation in the intestine from the

dairy itself that was causing problem

but either way I was having histamine

reactions and a variety of digestive

issues when I was incorporating large

amounts of dairy into my diet whether A1

or A2 the next thing they say here is

that the beta quesomorphin 7 or the

betaaseomorphins in general can have a

negative impact on cognitive function so

they say it is hypothesized that

similarly to pharmacologic opioids food

derived exorphins so the exogenous

morphines is what exorphins stands for

so exogenous opiate components from food

such as betaorphin 7 can also cross the

bloodb brain barrier it is likely that

they can bind to transporting proteins

that protect them from the hydraytic

action of peptidases in the blood and

then could become a substrate for the

carrier peptide transport system in the

bloodb brain barrier as beta

quesomorphin 7 is a muopioid receptor

agonist when it crosses the bloodb brain

barrier this could activate the

respective receptors of the central

nervous system a crucial component of

the internal messaging systems that

involve endorphins and ankle falins so

essentially what you're seeing is that

this peptide may actually have opiate

effects directly in the central nervous

system which is why I think people tend

to have brain fog loss of motivation and

changes into their libido when they go

on high dairy diets if they are

sensitive to beta quesomorphins so we

have some mechanisms here where this is

actually plausible and again these are

symptoms that I've seen with quite a few

clients incorporating dairy and removing

dairy solves this problem and again for

myself after spending almost one to two

years trying to make dairy work I was

having symptoms that mirror some of

these effects i was like oh maybe maybe

I don't react well to beta quasomorphins

and when I cut out dairy things got

significantly better so with that what

can you do to actually manage these beta

caseorphins do you have to cut out dairy

altogether or is there ways that you can

actually minimize these effects or some

workarounds in my perspective I think

there's a spectrum i don't think it has

to be all or nothing and the first step

to minimizing the impact of

quesomorphine if you know you have a

problem with quesomorphins is to try to

switch to A2 dairy options so this is

going to be things like A2 cows dairy

which is becoming much more popular in

Western countries there's sheep's dairy

there's goat dairy and there's buffalo

dairy so these animals there's also

camel dairy but I don't see that very

often on the on the grocery store

shelves but essentially these animals

are typically A2 variety animals where

you won't find the beta quesomorphine

peptide easily released from the casein

structure again because of that amino

acid substitution at position 67

basically I would try these dairy

options first for milk for yogurt for

cheese for any of these different

products now if that doesn't work if you

still don't tolerate the A2 varieties

after switching from A1 to A2 then the

next thing I would look to do is try A2

variety of cheeses that have been

fermented for a long period of time so

these are things like age gudas

parmesano reo aged pecarino romano sharp

cheddars aged manchego why well as we

talked about previously as the the

cheeses age they actually degrade some

of the uh opiate peptides the bacteria

or the aging process itself and then if

you have an A2 variety and the peptides

are further degraded then there may not

be enough of these problematic peptides

actually induce uh symptoms for you so

in that circumstance I've had some

clients who don't do well with most

dairy products like hey I can do cheese

no problem and I and it's usually

specific types of cheese and I think

this may be the reason why now another

caveat before we talk about the next

tier is amounts of the beta quesomorphin

7 may be important so you may be able to

get away with a small amount of it it's

not really that big of a deal so you be

may be able to moderate the dairy amount

per meal as well and switch to A2 and

find that it's not that big of a deal or

you may be able to have a small amount

of cheese and it's not really an issue

many people that I work with are fine

with small amounts of fermented dairy in

their meals it's just if they try to

make the diet all milk and orange juice

and stuff like this then it's when it

really starts to become a problem so

there's also the option of lowering and

adjusting the amounts and then gauging

based on your tolerance and kind of

going about this in a systematic way so

maybe you could do you know like an

ounce or 2 ounces of cheese with dinner

or something and see does that give you

a problem if it doesn't then it's

probably fine and again the protein in

the dairy the fats in the dairy there's

other beneficial peptides in dairy

products like cheese uh and then and

then the mineral content the calcium and

the potassium I think are all beneficial

so if you can tolerate it of course I

would recommend incorporating dairy but

if you have problems these are

strategies you can do in the meantime

then the last step is if all of the

casein is bothering you whether A2 A1

yogurt cheeses etc Then what you can

look to do is incorporate dairy fats and

whey proteins because the whey fraction

does not contain the beta quesomorphins

that you find in the casein fraction so

in that sense you could use whey instead

and you won't get that opiate effect as

an example myself I don't do well with

any casein and I'm also lactose tolerant

which is a very interesting setup but I

can actually tolerate whey protein

without much issue so I you incorporate

whey in my diet but I don't do very well

with casein so that's something you can

do and you can also incorporate dairy

fats like cream and butter into your

diet cuz again the casein component

inside the dairy fats should actually be

quite low so you're less likely to

actually have symptoms from it so in

that circumstance you can look to use

the dairy fats instead the only thing

I'd say there and again I have other

videos about this so I'll link them in

the description but if you don't do well

with the hormones in dairy that may be a

reason to be careful with some of the

dairy fats so while quesomorphins are

one of the major reasons as I was just

talking about there are other reasons

that you may not tolerate dairy and I

cover these options in another video

which you can check out Here

Edit:2025.04.28

毫无疑问，乳制品是一种营养丰富的超级食品，富含优质蛋白质、维生素、矿物质和健康脂肪。但如果你在饮食中添加牛奶、奶酪或酸奶后感觉更糟，你并不孤单。我曾与许多患者合作，他们在食用乳制品后出现奇怪的症状。我以前以为是乳糖的问题，但对一些人来说，问题更深层。

令人惊讶的是，对于很多人来说，真正的问题可能不是乳制品中的糖，而是乳制品酪蛋白释放的一种强效的类阿片肽：酪吗啡肽，更具体地说是β-酪吗啡肽-7（BCM-7）。

酪吗啡肽是牛奶酪蛋白消化过程中产生的类阿片肽。这些肽可以与你的μ-阿片受体结合，就像吗啡或羟可酮一样。这听起来可能有点不可思议，但确实有研究支持。

“β-酪啡肽 (βCM) 是一类链长为 4-11 个氨基酸的肽，所有肽均以对其阿片类活性至关重要的酪氨酸残基开头。”

资料来源：Cieślińska 等人，2022 年

其中研究最深入的是β-酪啡肽-7（BCM-7）。

 

并非所有奶牛的酪吗啡肽释放量都相同。真正的区别在于A1和A2奶牛体内β-酪蛋白的微小基因差异。

单个氨基酸变异（A1 中的组氨酸，A2 中的脯氨酸）会改变 BCM-7 在消化过程中的释放难易程度。A1 牛奶释放的BCM-7 数量更多。

“BCM-7 是由 β-酪蛋白 A1 和 B（但不是 A2）​​在胃肠道中连续水解产生的……A2 中的肽键比 A1 中的肽键具有更高的酶抗性。”

资料来源：Cieślińska 等人，2022 年

在牛奶中：

• A1 牛奶释放的 BCM-7 比 A2 牛奶多 4 倍
• 消化后，A2 牛奶中仍可能发现微量

在奶酪中：

• 存在于布里奶酪、高达奶酪、瑞士奶酪、蓝纹奶酪和林堡奶酪等软奶酪中
• 切达干酪等陈年奶酪随着时间的推移会分解，因此发生这种情况的可能性较小

> “软质、霉菌成熟的奶酪比陈年半硬质奶酪含有更多的 BCM-7。”

在正文中：

• BCM-7 具有很强的抗分解能力，使其能够穿过消化道，进入血液，并可能穿过血脑屏障。

• 组胺型反应：皮疹、荨麻疹、皮肤刺激
• 便秘或肠道蠕动改变
• 肠道不适或腹胀
• 脑雾和缺乏动力
• 性欲降低或荷尔蒙失衡

研究表明，BCM-7 能够激活TH2 免疫反应，增加 IgE、IgG1 和 CRP 等标志物。

“即使短期饮用 A1 牛奶也会显著增加促炎标志物……A2 牛奶没有显示出统计学差异。”

BCM-7 可以刺激肥大细胞组胺释放，导致皮疹、风团和耀斑型皮肤反应。

“β-酪啡肽可以通过免疫细胞释放组胺来诱发假过敏反应。”

• 减缓蠕动→便秘
• 可能刺激肠道内壁→腹胀和腹泻
• 可能会加剧现有的食物敏感或不耐受

BCM-7 与大脑的阿片类系统相互作用，可以破坏多巴胺-催乳素轴，影响性欲和睾酮。

BCM-7 可以穿过血脑屏障并与阿片类受体结合，从而可能导致：

• 脑雾
• 疲劳
• 缺乏动力

> “食物来源的外啡肽，如BCM-7，可以穿过血脑屏障并激活中枢神经系统阿片受体。”

• A2牛奶
• 山羊、绵羊或水牛奶制品
• 骆驼奶（如有）

这些通常不会像 A1 乳制品那样释放 BCM-7。

这些物质经过微生物和酶的变化，可以分解酪啡肽：

• 陈年高达奶酪
• 帕尔马干酪
• 罗马佩科里诺奶酪
• 曼彻格奶酪
• 夏普切达干酪

酪吗啡肽的效果似乎与剂量有关。根据我的经验，许多人服用少量酪吗啡肽后不会出现太大问题。

• 乳清蛋白（不含酪蛋白）
• 黄油或奶油（酪蛋白含量极低）

乳制品本身并非有害——这取决于具体情况和个体反应。如果你正在应对乳制品引起的一些奇怪症状，那么酪啡肽可能就是缺失的环节。幸运的是，只需稍加调整，许多人仍然可以享受乳制品，而不会产生负面影响。

• Cieślińska et al., 2022 – “Does a Little Difference Make a Big Difference? Bovine β-Casein A1 and A2 Variants and Human Health-An Update.”
• Demirel & Çak, 2018 – “Effect A1 and A2 Milk Beta-Casein Gene on Health”
• Lambers et al., Duarte-Vazquez et al., Haq et al., Pal et al., Ho et al., Jianqin et al., Stepnik & Kurek

https://mikefave.com/is-this-unknown-protein-in-dairy-destroying-your-health/

Edit:2025.04.28

讨论列表 AKP讨论 查看原帖及回帖