睡个好觉是我能做的最好的时间投资之一,因为睡眠给了我生活中表现良好所需的能量和头脑清醒,还让我更加警觉、精力充沛、积极进取、富有创造力和更快乐。
相反,每当我睡眠不足时,我就会更容易分心,做任何事都更糟糕, 我也不会那么喜欢做事。对我来说,睡眠不好比饮食不良或缺乏运动对我造成的生理和精神损害要严重得多。
在大学期间,我曾长期每晚只睡五到六个小时。回想起来,减少睡眠是一件非常无效率的事情。我的表现更差,元认知也更差。此外,我经常在做错的事。即使在做对的事时,我也很容易分心。回想起来,我经常处于半“醉”状态,一切都模糊不清。
现在,我的睡眠质量很好,改善睡眠是我做过的最有成效的事情之一。
清醒是一种“低水平脑损伤”,睡眠是重置大脑的必要条件,因为有大量细胞过程只能在睡眠期间进行。这些过程包括清除代谢废物、重新调节大量神经元基因的表达、执行数百项细胞内务管理任务以及突触调节。
因此,睡眠不足会导致神经系统失调。而我的神经系统负责很多我要重视的东西。
睡眠对于良好的模式识别、记忆巩固、代谢完整性、激素健康、执行功能、情绪控制、注意力、创造力和生活享受是必要的(但不是充分的)。
良好的睡眠对情绪稳定也很重要。没有一种精神疾病会导致睡眠不足——双向因果关系。此外,良好的睡眠对意志力至关重要——意志力对其他一切都至关重要。
以下是几种帮助我改善睡眠的策略。
目录
我现在将简要讨论一下每一个策略。
我发现,改善睡眠质量的最佳方法之一就是每天在同一时间(+/- 30 分钟)上床睡觉。重要的不仅是每晚的总睡眠时间,还有我的睡眠时间如何与我的昼夜节律保持一致,这会改变睡眠阶段的时间。
比如,如果我比平时晚睡,哪怕只晚一个小时,即使睡眠时间一样长,我的睡眠质量也会变差。第二天我会感觉更没精神,而且拖延得更厉害。我认为我比其他人对此更敏感。
我喜欢的睡眠时间是 22:00-06:00。幸运的是,我天生就是一个早起的人,我不需要与遗传影响的睡眠类型作斗争。
似乎有证据表明,在真正自然的条件下,例如当人们远离电子产品时,大多数人的睡眠类型都有些相似,大多数人更喜欢在 22:00 之前上床睡觉。即使总睡眠时间保持不变,大多数人如果早睡而不是晚睡,睡眠质量也会更好。
我确保我的卧室非常暗(暗到我基本上什么都看不见)。我发现,即使我主观上不认为光线会打扰我,即使是微弱的光线也会使我的睡眠变差。
人眼对哪怕是极少量的光子都非常敏感,每当视网膜捕捉到亮度时,就会向脑干网状激活系统的不同区域发送信号,进而引发乙酰胆碱和去甲肾上腺素释放的细微变化,导致睡眠质量下降和微觉醒。
有些人声称,在非黑暗环境中可以“睡得很好”。然而,“睡得很好”远非最佳状态,我发现,将卧室保持黑暗是一个简单但有效的方法,投资回报率很高。
我使用遮光窗帘,黑色胶带遮住所有电子灯。我不使用睡眠眼罩,因为当我用时总是在睡觉时扯掉。
我确保我的房间足够冷。一年四季,我还使用由 80% 尼龙和 20% 聚乙烯制成的冷却毯,可以吸收皮肤上的热量并将其传导出去,使皮肤温度降低 2-5 摄氏度。
在夏季,我会使用 Chili Pad,显著改善了我睡眠的多个方面,例如睡眠潜伏期(入睡所需的时间)和深度睡眠。
因为它每年能提高我 3-4 个月的生产力,所以我认为 Chili Pad 是我做过的最有利润的投资之一。
我还尝试了 Ooler 睡眠系统,比 Chili Pad 稍微“好”一点。Ooler 系统的主要优点之一是可以设置为早上加热。但是,我也可以通过将 Chili Pad 连接到一个在早上 5 点自动关闭的智能插头来实现同样的效果
我的一个朋友睡在 Eight Sleep 床垫上,尽管价格昂贵,但他非常喜欢它。
我很少喝咖啡因。即使晚上喝几口绿茶,我的睡眠也会受到影响。我遇到过很多人,他们认为下午晚些时候喝咖啡因不会影响睡眠。根据科学数据,这是胡说,多导睡眠图可以检测到睡眠质量的明显下降(即使对于那些认为自己的睡眠不受影响的人来说也是如此)。
我在这里更详细地讨论了咖啡因。
酒精最有害的影响之一就是对睡眠的不利影响。
上次我喝了两杯龙舌兰酒(我很少喝酒),我的 REM 睡眠和 SWS 数值大幅下降,体温升高,心率变异性降至最低,我的 Oura 睡眠和准备度评分读数极低。客观数据与我的主观体验非常吻合。
我的一些朋友在晚上喝酒(或THC)来放松,甚至专门用来帮助入睡。然而,众所周知,酒精除了会影响睡眠潜伏期(入睡所需的时间)之外,还会在其他方面影响睡眠。此外,如果长期饮酒,停酒后很可能会出现反弹性失眠,从而形成恶性循环。
我喜欢 Oura 手环,尽管我还没有尝试过其他睡眠追踪器。对我来说,我的 Oura 数据通常与我对睡眠质量的主观感受非常吻合。
我有几个朋友即将患上“睡眠追踪器引发的睡眠障碍”,因为他们对自己的指标过于神经质。数据越多并不总是越好,对于疑病症患者或过度神经质的人来说,睡眠追踪器可能弊大于利。
临睡前吃一顿小餐对我的主观和客观睡眠数据影响不大。然而,临睡前吃一顿大餐需要大量能量进行消化过程,这会导致心率和体温升高,降低我的心率变异性 (HRV),让我醒来时感觉昏昏沉沉。
下面是两张我睡眠心率的截图。左边是“正常”心率,右边是睡前吃过一顿大餐后的心率。我发现深度睡眠和 REM 数字的变化相当惊人。
众所周知,睡前吃大量食物也会干扰生长激素的分泌,而生长激素的分泌大多发生在夜晚的前三分之一时间。
每当我晚上吃适量的碳水化合物时,我的睡眠似乎就会改善。相反,当我晚上不吃任何碳水化合物时,我通常很难入睡。这可能是由于胰岛素对血清素系统的刺激作用和对食欲素系统的抑制作用,这两个系统与睡眠调节密切相关。
然而,如果我在睡前吃了很多“垃圾”碳水化合物,我需要更长的时间才能进入深度睡眠,而且第二天尽管我的总睡眠时间有所增加,但我还是会感到有点昏昏沉沉。
我在饮食部分更详细地讨论了碳水化合物。
研究一致发现,运动可以改善睡眠质量,包括增加总睡眠时间和慢波睡眠。这与我的个人经历非常吻合。
如果我几天不运动,我的睡眠质量就会下降。然而,进行剧烈体育锻炼的一个缺点是,会使我的睡眠需求增加大约一小时。
每当我在临睡前锻炼时,我就会花更长的时间入睡,而且我的心率和体温在前半夜仍然很高,使我无法正常进入深度睡眠。这可能是由于代谢率上升和皮质醇水平微升造成的。睡前洗个冷水澡似乎有点帮助。
我很快会更详细地讨论锻炼。
起床后,我会使用 10,000lux 的日光灯作为我的台灯。我认为,只要累积光照、亮度和波长相同,光线是来自太阳还是灯并不重要。
因为日光亮度显然比人造光要亮得多,所以我尝试通过使用日光灯约 2 小时来部分解决这个问题。我使用的日光灯是 Beurer TL41。
醒来后,我会在最高设置下使用光疗眼镜 (Luminette 3) 约 15 分钟。这样做的主要好处有两个。首先,眼镜会以适当的强度将光线直接照射到我的视网膜上。其次,我在进行早晨例行活动(例如上厕所、穿衣服、伸展身体等)时会将自己暴露在光线下。这两件事是传统日光灯无法实现的。
一位朋友在冬季容易患抑郁症,通常使用微量依他普*来应对季节性精力和情绪低落。他声称,每天使用 Luminette 3 30 分钟可以触发“开关”,而普通光疗则无法做到这一点。
我尽量让自己全天都接触明亮的光线。例如,当我在家工作时,我的日光灯通常会亮几个小时。下午我还会戴一次光疗眼镜,每次大约 15 分钟。
短期来看,早晨接触明亮的光线会刺激早晨皮质醇的释放(这是件好事)。此外,通过直接视网膜缝投射,还会增强血清素信号。皮质醇的增加加上血清素传递的增加有助于我第二天的精力和情绪。早晨的明亮光线被认为也会影响多巴胺系统。
从长远来看,早晨经常接触明亮的光线可以同步我的昼夜节律,增强皮质醇觉醒反应 (CAR),提高各种神经递质的水平,改善体温模式。即使我几天不接触明亮的光线,这些效果也会持续下去。
通过大量的自我实验,我发现,对我来说,夜间适量的蓝光对我的睡眠的负面影响(无论是主观影响还是根据 Oura 数据)远小于我最初认为的。不过,与所有事物一样,夜间蓝光敏感度可能存在个体差异,如果可以舒适地做到这一点,最好避免接触。
我睡前服用 400 毫克非氧化镁、5 克甘氨酸和 500 毫克牛磺酸。所有这些都对我的睡眠质量产生了微小但可衡量的影响。甘氨酸的功效特别让我惊讶。我在补剂部分更详细地讨论了所有这些。
褪黑素是一把双刃剑。
据认为,长期服用 0.3-0.5 毫克的小剂量是安全的。褪黑素不仅有助于调节昼夜节律,还可能有助于入睡和提高睡眠质量,因为褪黑素是一种降温剂。
我目前不使用褪黑素,因为我觉得我已经有很强的昼夜节律了。此外,风险和负面影响,尤其是对内分泌系统的影响,可能大于益处。有趣的是,每当我开始服用时,头几天我都会在凌晨 4 点醒来,非常警觉,精力充沛,大概是因为我的昼夜节律因接触褪黑素水平的人工峰值而“混乱”。然而,这种情况似乎很快就会消失。
几个朋友使用 0.5 毫克缓释褪黑激素,效果良好。
除了褪黑激素外,还有多种激素会影响睡眠。这些激素包括睾酮、雌二醇、黄体酮、甲状腺激素、生长激素、IGF-1、瘦素、胰岛素和皮质醇。我在这里更详细地讨论了其中一些激素。
随着年龄的增长,REM 和 SWS 的次数会越来越少,而夜间第 1 和第 2 阶段(浅睡眠)的次数会越来越多。这在一定程度上与生长激素的下降有关。我让父亲短期服用低剂量的生长激素后,他说睡眠质量得到了极大的改善,醒来后感觉精神焕发。睡眠质量的提高是人们尝试生长激素疗法后最常见的观察结果之一。
我的一个朋友患有睡眠呼吸暂停。因此,他很少处于慢波睡眠 (SWS) 状态。在接受治疗之前,他总是感到疲倦,需要超过 9 个小时的睡眠才能感觉至少得到部分休息,患有所谓的“白天过度嗜睡” (EDS)。使用 CPAP 设备和一种名为“Velumount”的设备对他有很大帮助,并且还减少了体脂。
睡眠呼吸暂停是一种严重的疾病,如果不加以治疗,可能会缩短人的寿命。目前约有 80% 的睡眠呼吸暂停患者尚未得到诊断,患者往往甚至没有意识到自己经常醒来,在非快速眼动浅睡眠和短暂的半意识清醒之间摇摆不定,这阻止人们进入恢复性深度睡眠,最终在各个方面降低健康、寿命和幸福感。
最好在睡眠实验室中检查睡眠呼吸暂停情况。
几个朋友发现,当他们压力大、思绪混乱时,睡前冥想特别有用。我个人无法在晚上冥想,因为我不够警觉和“入定”。我在这里更详细地讨论了我的冥想经验。
我尝试过各种安眠药,偶尔,我仍然会使用其中两种。因为安眠药在技术上不是生活方式干预,所以我在这里单独讨论它们:助眠药(“安眠药”)。
我之所提到这,只是因为我觉得这很有趣。我发现一晚睡得很少会对我产生强烈的刺激作用,大概是因为能提高谷氨酸、多巴胺和皮质醇的水平。
因此,睡眠剥夺有时被用来治疗抑郁症。不幸的是,这种兴奋剂和抗抑郁剂的效果不会持续很长时间,而且往往会以崩溃告终。
我在这里更详细地讨论了其他常见(但经常被忽视)的疲劳原因:“我一直都很累”——12 个被忽视的疲劳原因
本文是*“我如何通过生物黑客手段增强活力”的一个小节。
本内容基于作者的个人研究、观点和个人经历。仅供参考和娱乐,不构成医疗建议。作者不认可在没有合格医生直接监督的情况下使用补剂、药物或激素。人们不应该因为在网上读到的内容而忽视专业医疗建议或延迟寻求医疗建议。
https://desmolysium.com/sleep/
Edit:2024.12.23
本期节目主要讨论了利用科学方法优化睡眠、学习和代谢的策略。首先解释了生物钟与光照的关系,指出月光、烛光等弱光不会影响生物钟,而过强的红光则会干扰睡眠。还强调了透过窗户的阳光虽然也能调节生物钟,但效果较弱,建议尽量进行户外光照。季节变化会影响昼夜长度,进而影响褪黑素的分泌,影响情绪和代谢。 还详细讲解了运动与生物钟的关系,指出最佳运动时间为醒来后30分钟、3小时和11小时。此外还介绍了神经可塑性及其在学习中的作用,指出睡眠和非眠深休(NSDR)可以增强神经可塑性,提高学习效率。睡眠期间的感官刺激(如气味或声音)可以增强记忆巩固。 在饮食方面,食物会影响神经递质水平,进而影响睡眠、清醒和情绪。富含酪氨酸的食物(如坚果和红肉)会促进多巴胺和去甲肾上腺素的分泌,而乏食则会提高警觉性。进食会引起体温升高,影响生物钟,因此建议根据一天中的时间安排饮食。 最后强调了体温在调节生物钟和代谢中的重要作用,建议进行自我实验,观察不同因素(如光照、运动、饮食和体温)对睡眠、注意力和清醒状态的影响,从而找到最适合自己的优化策略。
解答大家最常问到的问题,这些问题都围绕着如何利用科学方法来提升警觉性、增强学习能力和改善睡眠质量。节目中探讨了最佳运动和进食时间、如何合理安排光照以及如何策略性地调节体温以影响神经系统。
生物钟与光照:月光、烛光与红光
月光、烛光和壁炉的火光,即使看起来很明亮,也不会在夜间重置生物钟,让人误以为是白天。这是因为视网膜中负责感知光线的内在光敏视网膜神经节细胞(ipRGCs)会根据一天中的时间调整其敏感度,它们对日出日落时低角度阳光中的蓝黄对比最为敏感。因此,这些细胞在夜晚对月光、烛光和壁炉火光的反应较弱,不会发出白天信号。
关于红光,原则上不会刺激ipRGCs,但市面上许多红光产品的光线强度过高,仍然会干扰睡眠。因此,如果想在晚上使用红光,必须将其调暗至非常低的亮度。
窗户透过的阳光也能调节生物钟,但效率远低于户外阳光,建议尽可能进行户外光照。可以使用免费的照度计APP测量不同环境下的光照强度,进行更精细的调节。眼镜或隐形眼镜不会显著影响通过窗户的光照效果,因为其设计目的是将光线聚焦到视网膜上。
季节变化与情绪、新陈代谢
地球的倾斜角度导致一年中不同季节的昼夜长度不同。昼夜长度的变化会影响褪黑素的分泌。褪黑素由血清素合成,血清素与平静和幸福感相关,而多巴胺则促进行动和奖励感。较长的日照时间会抑制褪黑素分泌,而较短的日照时间则会延长褪黑素分泌时间。理解光照对褪黑素的影响,有助于根据季节变化调整行为,例如在情绪低落时增加光照时间。
运动与生物钟:最佳运动时间
关于运动,最佳时间点通常在醒来后30分钟、3小时和11小时(醒来后约11小时,体温通常达到峰值)。清晨运动可以建立身体的预期机制,让人更容易在特定时间醒来,但仍需配合光照。剧烈运动可能影响睡眠,建议选择中等强度的运动。
神经可塑性与学习:睡眠与非眠深休
神经可塑性是神经系统对经验做出改变的能力。睡眠和非眠深休(NSDR)都能增强神经可塑性,提高学习效率。研究表明,在睡眠期间给予与学习内容相关的感官刺激(如气味或声音),可以增强记忆巩固。非眠深休是一种无需睡眠就能提高学习效率的方法,建议每90分钟的学习后进行20分钟的非眠深休。
学习与神经增强剂
关于神经增强剂,我的立场是谨慎的。大多数神经增强剂都包含兴奋剂成分(如咖啡因)和胆碱能增强剂,这可能导致学习效率的短期提升,但长期来看,其作用机制并不完善,且可能存在副作用。
体温与生物钟:冷暴露与热暴露
体温在调节生物钟和代谢中起着关键作用。体温在一天中呈周期性变化,最低点通常在凌晨4点左右,最高点在下午4-6点左右。受冷(如冷水浴)可以提前生物钟,而受热(如桑拿)则可以延后生物钟。进食也会引起体温升高,影响生物钟。
饮食与神经递质:食物与情绪
食物会影响神经递质水平,进而影响睡眠、清醒和情绪。富含酪氨酸的食物(如坚果和红肉)会促进多巴胺和去甲肾上腺素的分泌,而乏食则会提高警觉性。进食量也会影响睡眠,过饱会让人昏昏欲睡。
自我实验:找到最适合自己的策略
建议大家进行自我实验,记录每天的光照、运动、饮食和体温等信息,观察其对睡眠、注意力和清醒状态的影响,从而找到最适合自己的优化策略。 记住,这并非要建立一个严格的日程表,而是要找到最有效的变量,并调整那些对自己不利的因素。 循序渐进地进行自我实验,一次只调整一两个变量,才能更好地了解自身生理规律。
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02:17 月光、烛光和壁炉火光不会在夜间重置生物钟。
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02:45 眼中的感光细胞对蓝黄对比最敏感,对月光和火光不敏感。
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03:16 红光原则上不会刺激唤醒大脑和生物钟的感光细胞,但市面上大多数红光产品太亮。
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05:04透窗的阳光调节生物钟比直接照射阳光慢得多,但戴眼镜或隐形眼镜不会影响效果。
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05:58 季节变化会影响生物钟,光照会影响褪黑素水平,进而影响情绪和代谢。
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09:57 补充电解质对于大脑和身体功能至关重要。
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11:19 睡眠环境温度的控制对于高质量睡眠至关重要。
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12:24 肾上腺素和去甲肾上腺素基本相同,都会刺激兴奋和运动的欲望。
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12:52 最佳运动时间为醒来后30分钟、醒来后3小时和醒来后11小时。
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14:39 大脑和神经系统具有可塑性,会根据经验发生改变,规律的作息会增强这种可塑性。
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17:55 睡眠期间的感官刺激可以增强学习和记忆。
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21:17 补充维生素、矿物质和益生菌对健康至关重要。
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23:40 非眠深休(NSDR)可以加速学习和记忆巩固。
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25:05 目前市面上的大多数益智药效果有限,不能替代睡眠和休息。
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27:33 体温是生物钟影响身体细胞和组织的方式之一,冷水浴可以调节生物钟。
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31:41 饮食时间会影响生物钟,调整饮食时间可以帮助快速适应新的时区。
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32:04 高蛋白低热量的零食有助于控制热量摄入并补充蛋白质。
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32:36 食物会影响神经递质水平,进而影响睡眠、清醒和情绪。
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34:51 进食会引起体温升高,影响生物钟。
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35:28 建议进行自我实验,观察不同因素对睡眠、注意力和清醒状态的影响。
Andrew Huberman00:00
Welcome to huberman lab essentials, where we revisit past episodes for the most potent and actionable science space tools for mental health, physical health and performance. I'm Andrew huberman and i'm a professor of neurobiology opposite logy at stanford school of medicine. Today is episode through the podcast, and IT is office hours. Office hours, as many of you know, where students come to the office of the professor, sit down and ask questions requesting clarification about things that we're confusing or to simply go down the road of expLoring a topic with more depth than detail.
Andrew Huberman00:37
Somebody asked, what is the role of moonlight and fire and presume they mean fireplace or candler things in that sort in setting circadian rythm? Is IT okay to view moonlight at night? Or will that wake me up? Will a fire in my fireplace or using candle light be too much light? Great question. Turns out that moon light, candle light and even a fireplace, if you have one of these roaring fires going in the fireplace, do not reset your circadian clock at night and trick your brain into thinking that it's morning, even though if you've ever SAT close to a fireplace or even a candle, that light seems very bright. And there are two reasons for that that are very important.
Andrew Huberman01:22
The first one is that these neurons in your eye that had discuss in the previous episode, these melon ops and gangly and cells, also called intrinsically photo sensitive gangling cells, those cells adjust their sensitivity across the day, and those cells respond best to the blue, yellow contrast present in the rising and setting sun, so called low solar angle sun, also discussing the previous episode. But those cells adjust their sensitivity such that they will not activate the the triggers in the brain that convey daytime signals when they view moonlight, even a full moon, or really bright moon, or fire. Because we talked about just how crucial IT is to avoid bright lights between the hours about ten pm and four A M, except when you need to view things for sake of safety or or worker and so forth.
Andrew Huberman02:17
I also received a lot of questions about red light. In principal, red light will not stimulate the melon ops in retinal neurons that wake up the brain and circuit I an clock and signal daytime. However, most of the red lights, in particular the red lights that come on the sheet of these products that people are supose to view the um in order to access the number of know the effects, those are way too bright and would definitely wake up your body and brain.
Andrew Huberman02:45
So if you're thinking about red light for sake of avoiding the negative effects of light later in the day and at night, then you want that red light to be very, very dimmed, certainly much dimmer than is on most of those commercial products. Now do you need red lights? Know, although red lights are rather convenient because you can see pretty well with them on.
Andrew Huberman03:03
But if they're dim, they won't wake up the circulating clock. They won't have this dopamine disrupting thing that we talked about in the previous podcast. Okay, a huge number of people asked me about light through window.
Andrew Huberman03:16
Setting your car in clock with sunlight coming through a window is going to take fifty to one hundred times longer. You can download the free APP light meter. You can have a bright day outside, or some sunlight hold up that APP. Take a picture, it'll tell you how many locks are in that environment. Now close the window, and if you want close the screen or don't open the screen, you can do all sort of experiments.
Andrew Huberman03:37
You'll see that I will, at least half the amount of locks and IT doesn't scare linearly meaning lets say I get uh ten thousand locks outside, five thousand looking out through an open window and then I close the window and it's twenty five hundred locks. IT does not mean that you just need to view that sunlight for twice as long if its half as many lucks okay does not like twenty a hundred looks means you need to look for ten minutes and um five thousand looks means you look for five minutes IT doesn't scale that way just because the biology doesn't work that way. Best thing to do is to get outside, if you can, if you can.
Andrew Huberman04:13
Next best thing to do is to keep that window open. IT is perfectly. Find a way prescription lens is in contacts. Why is IT okay where prescription lens is in context when those are glass also, but looking through a window diminishes the effect? Well, we should think about this.
Andrew Huberman04:29
The lens is that you wear in front of your eyes by prescription or on your eyes, are designed to focus the light on to your neural retina. So let's think about why i'm making some of these recommendations because I think IT can really empower you with the ability to change your behavior in terms of light viewing and other things depending on time of year, depending on other lifestyle factors. The important point understand is that early in the day, your central circadian clocks and all these mechanisms are looking for a lot of light.
Andrew Huberman05:04
okay? I want talk about seasonal changes in all these things as they relate to mood and metabolism. So as all of you know, the earth spends once every twenty four hours on its access.
Andrew Huberman05:16
So part of that day we're bathe in sunlight depending on where we are. The other half of the day, or part of the day we're in darkness. Youth also travels around the sun.
Andrew Huberman05:24
Three hundred and sixty five days is the time that IT takes one year to travel around that sun. The earth is tilted. It's not perfectly upright, so the earth is tilted on its access.
Andrew Huberman05:39
So depending on where we are in that three hundred and sixty five day journey, and depending on where we are in terms of hemisphere in northern hemisphere, southern hemisphere, some days of the year are longer than others. Some are very short, some are very long. The at the quarter, you experience less variation in day life from there for nightline.
Andrew Huberman05:58
And if you're closer to to the polls, you're gonna ence some very long days and you're also going to experience some very short days depending on which pull your at and what time of year IT is. A simple way to put this is depending on time of year, the days are either getting shorter, getting longer. Now every selling your body adjust its biology according to daylife.
Andrew Huberman06:19
Except your brain, body and cells don't actually know anything about daylife. IT only knows night link. And here's how works.
Andrew Huberman06:28
Light inhibits melatonin powerfully. If days are long and getting longer, that means meet tony is reduced. If days are getting shorter, that melotte in signal is getting longer.
Andrew Huberman06:45
So every selling your body actually knows external day length and therefore time of year by way of the duration of the military and signal by understanding that light and extended daylight and hibbing loiterin and military and attends to be associated with a more depressed to reduced functioning of these kind of activity, driving and mood elevating signals, and understanding that you have some control over melatonin by way of light, including some light, but also our official light, that should empower you, I believe, to make the adjustments that if you're feeling low, you might ask, how much? Why am I getting when am I getting that light? Because sleep is also important for restoring mood, right? So you need sleep.
Andrew Huberman07:28
You can't just know, just crush militant a and across the board and expect to feel good because then you're not going to fall asleep and stay asleep millett in, not incidentally, comes from is synthesized from serotonin. Serotonin is an era transmitter that is associated with feelings of well being provided at proper levels, but well being of a particular kind, well being associated with quiescent and calm. And the feeling that we have enough resources in our immediate conditions is the kind of thing that comes from a good meal, or sitting down with friends, or holding a loved one, or conversing with somebody that you really bond with.
Andrew Huberman08:10
Serotonin does not stimulate action. IT tends to stimulate stillness. Very different than the neo modulator dopamine, which is a reward, feel good, nor modulator that stimulate action. And actually depine is the precursor to APP element to a general which actually puts us into action.
Andrew Huberman08:30
There is actually made from doping, right? So you can start to think about light as a signal that is very powerful for modulating, things like sleep and wake for this, but also ceretani levels, military in levels. And I talked about this previously, but I mention once more that light in the middle night reduces dopamine e levels to the point where can start causing problems with learning a memory and mood.
Andrew Huberman08:54
That's one powerful reason to avoid brought light in the all the night. I'd like to take a quick break and think one of our sponsors element element is an electoral light drink that has everything you need and nothing you don't that means the electorate so do magnesium and peasants um in the correct ratio but no sugar. We should all know that proper hydration is critical for optimal brain and body function.
Andrew Huberman09:17
In fact, even a slight degree of dehydrogenation can diminished cognitive and physical performance to a considerable degree. Is also important that you're not just hydrated but that you get adequate amount of electronic light in the right ratio. Drinking a pack of element dissolved in water makes IT very easy to ensure that you're getting adele amounts of hydration and electronic lights to make sure that i'm getting proper amounts of both.
Andrew Huberman09:38
I dissolve one packet of element in about sixteen to thirty two ounces of water when I wake up in the morning, and I drink that basically first thing in the morning, i'll also drink a active element dissolved in water. Drink any kind of physical exercise that i'm doing, especially on hot days when i'm sweating a lot, losing water. And electorates, there are a bunch of different gray taste flavorous development.
Andrew Huberman09:57
I like the watermelon, like the razor, like the situation. I like all of them. If you'd like to try element, you can go to drink element that com slash huberman to claim an element sample pack with the the purchase of any element drink mix.
Andrew Huberman10:09
Again, that drink element spell L M N T. So it's a drink element dot com slash huberman to claim a free sample pack. Today's episode is also brought to us by eight sleep. Eight sleep make smart mattress covers with cooling, heating and sleep tracking capacity. Now I was spoken before in this podcast about the critical need for us to get adequate amounts of quality sleep each night.
Andrew Huberman10:29
Now one of the best ways to ensure a great night sleep is to ensure that the temperature of your epp environment is correct, and that's because in order to fall and stay deeply asleep, your body temperature actually has to drop by about one to three degrees. In order to wake up feeling refreshed, energize, your body temperature actually has to increase about one to three degrees eight sleep makes IT very easy to control the temperature of your sleeping environment by allowing you to programme the temperature of your mattress cover at the beginning, middle and end of the night. I've been sleeping on an eight sleep matters cover for nearly four years now, and IT has completely transformed and improved the quality of my sleep.
Andrew Huberman11:04
Sleep recently launched the newest generation of the pod cover called the pod for ultra. The pod for ultra has improved cooling n heating capacity. I find that very useful because I like to make the bed really cool at the beginning of the night, even called her in the middle of the night, and warm as I wake up.
Andrew Huberman11:19
That's what gives me the most slow wave sleep and rapid eye mom sleep. If you'd like to try and eight sleep mattress cover, you can go to a sleep dot com slash huberman to access their black friday offer. Right now, with this black friday discount, you can save up to six hundred dollars on their pod for ultra.
Andrew Huberman11:35
This is eight sleeps bigger sale of the year eight. Sleep currently ships to the U. S.
Andrew Huberman11:40
A, canada, U. K. Select countries in the eu. In australia. Again, that's a sleep dot com slash huberman throughout this podcast. And in previous episodes i've been mentioning nem modulators, things like serotonin and doping, which tend to buy a certain brain circuits and things in our body to happen, in certain brain circuits and things in body to happen.
Andrew Huberman12:00
One of the ones i've mentioned numerous times is epiphone, which is a neuromodulation that tends to put us into action, make us want to move. In fact, when it's released in high amounts in our brain body, IT can lead to what we call stress, where the feeling of being stressed several people asked me, what's the difference between epinal and a jinin? A journey is secreted from the adjunct glands, which sit right above our kidneys.
Andrew Huberman12:24
Evenement is the exact same molecule, except that it's released within the brain. Epinephrine, renal are basically the same thing. And they take to stimulate, agitating, the desire to move. Got a lot of questions about exercise.
Andrew Huberman12:39
What forms of exercise are best for sleeping? Well, when should I exercise is set up? There are basically two forms of exercises that we can talk about, although of course, I realized there are many different forms of exercises, much more numerous to this.
Andrew Huberman12:52
But we can talk about cardiovascular exercise, where the ideas to repeat a movement over and over and over continuously so that be like running, biking, rolling in the cycling this kind of thing or there's resistance exercise where you're moving, lifting, personally putting down also um things of progressively. Have you have your weight that you couldn't do continuously for for thirty minutes? Now you will see some places a robic exercise best done in the morning and way train is best done in the afternoon.
Andrew Huberman13:21
I think there is far more individual variation than that. Um I think there are, however, a couple of windows that the exercise science literature and the circular leader points to as windows related to body temperature in which performance injury um in which performance is is optimize, injuries reduced and so on. And those tend to be thirty minutes after waking, three hours after waking and the later afternoon, usually eleven hours after waking, which is when temperature tends to peak.
Andrew Huberman13:56
A note about working out first thing in the morning. Last time we talk about non photic face shifts. If you exercise first thing in the morning, your body will start to develop in the anticipatory circuit.
Andrew Huberman14:07
There's actually plasticity in these circuit, an circuits that will lead you to want to wake up at the particular time that you exercise the previous three or four days. So that can be a powerful tool. But you still want to get light exposure because IT turns out that light and exercise converge to giving even bigger wake up signal to the brain and body.
Andrew Huberman14:27
So I want to think about that. Some people find that they exercises late in the day. They have trouble sleeping. In general, intense exercise does that. We're as the kind of lower intensity exercise doesn't.
Andrew Huberman14:39
Many of your questions were about neural plasticity, which is the brain and nervous systems ability to change in response to experience. There was a question that asked whether not these really deep biological mechanisms around wakefulness time of waking sleep at that a we're subject to neural plasticity. And indeed, they are. Some of that plasticity is short term and some of IT is more long term. There's a really good analogy here, which is if you happen to eat on a very tight schedule where every day, say at A M noon and seven pm, is when you eat your food, not suggested you do this, but let's say you were to do that for a couple days.
Andrew Huberman15:20
After a few days, you would start to anticipate those meal times where no matter where you were in the world, no matter what was going on in your life, about five to ten minutes before those meal times, you would start to feel hungry and even agitated, which is your body's way of trying to get you to ford for food. And that's because of some peptide signals that come from the periphery, from your body, things like hyper creating erection, that signal aled to the hyperbole omers and brain stem to make you active in a certain look for food and feel hungry. So there's got an anticipatory circuit that's a chemical circuit.
Andrew Huberman15:57
But eventually, over time, the neurons, the neural circuits that control hyper create nursin, would get tuned to the neural circuits that are involved in eating and maybe even even smell and taste to create a kind of eating circuit that's unique to your pattern, to your rythm. The same thing is true for this waking and exercise and other schedules, including all trade and schedules, if you wake up in the morning and start getting your sunlight, you start exercising in the morning, are you exercised in the afternoon? Pretty soon your body will start to anticipate that and start to secrete hormones and other signals that prepare your body for the ensuing activity of waking up or going to sleep.
Andrew Huberman16:39
So if you get onto a pattern or hythloday, even if that rythm isn't down to the minute, you'll find that there's plasticity in the circuits and IT becomes easier to wake up early if that's your thing, or exercise in a particular day, if that's your thing. That's the beauty of neural plasticity. A number of people asked, what can I do to increase plasticity? And that really comes in two forms.
Andrew Huberman17:03
There's plasticity that we can access in sleep to improve rates of learning and depth of learning from the previous day or so. And there's this n sdr non sleeps depress that can be done without sleeping to improve rates of learning and death of retention at set us. So let's consider the both, and you can incorporate these protocols, if you like.
Andrew Huberman17:26
Again, these are based on quality per reviewed studies. First, let's talk about learning in sleep. This is based on some work that i'll provide a reference for that was published in the journal science excEllent journal.
Andrew Huberman17:39
Matt Walker also talks about some of these studies done by others in his book, why we sleep. The studies, just to remind you, are structured the following way, and an individual is brought into a laboratory. Look, does a spac memory task.
Andrew Huberman17:55
So there tends to be a screen with a bunch of different objects popping up on the screen in different location. So I might be a bulldog's face. There might be a cat, then IT might be an apple, then IT might be a pen in different locations. And that sounds trivial ly easy.
Andrew Huberman18:09
But with time, you can imagine IT gets pretty tough to come back a day later and remember if something presented in a given location was something you've seen before, and whether not IT was presented that location or a different location, you had enough objects and changed locations enough. This can actually be quite difficult in this study. The subjects either just went through the the experiment, or a particular oder was released into the room while they were learning, or a tone was played in the room while they were learning.
Andrew Huberman18:40
And then during the sleep of those subjects the following night and the following night, this was done repeatedly for several nights. The same older or tone was played while the subjects were sleeping. They did this in different stages of sleeping on rim sleeps. And but I move in sleep and sleep. They did this with just the tone in sleep.
Andrew Huberman19:05
If they, if the subjects that had the older, but not the tone they had, they did IT with putting the tone if they had the older, while learning so basic, all the controls, all the things you'd want to see done to make sure that IT wasn't some indirect effect of modulator effect. 嗯。 And what they found was that providing the same stimulus, the older, if they smaller, oder or a tone, if the subjects heard a toned while learning, if they just delivered that outer or tone while the subject slapped, rates of learning and retention of information was significantly greater.
Andrew Huberman19:41
This is pretty cool. What this means that you can kill the subconscious brain, the asleep brain, to learn particular things Better and faster. So how might you implement this? Well, you could play with this if you want.
Andrew Huberman19:54
I don't see any real chAllenge of this provided the older and is a safe one and doesn't wake you up in the tone is a safe, uh, safe one and doesn't wake you up. Um you could do this by having a metronome, for instance, while learning something, playing in the background or particular music, and then have that very faintly while you sleep. So you could apply this, if you like, and and try this.
Andrew Huberman20:15
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Andrew Huberman20:35
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Andrew Huberman21:17
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Andrew Huberman21:44
Again, go to drink A G one dot com slash huberman to claim this special offer. The other former neuroplasticity not a neuroplasticity that you're amplifying by listening to tones or um smelling oders in sleep, but the neural plastic that you can access with non sleep deep pressed so n sdr non sleep depressed as well as short twenty minute nps which are very close to non sleep deep breath because people rarely drop into deep states of sleep during short naps unless they're very sleep deprived. N sdr has been shown to increase rates of learning when done for twenty minute bouts for a proto match, an approximately the ninety minute bout of learning.
Andrew Huberman22:28
So what am I talking about? Ninety minute cycles are these all tradition cycles that i've talked about previously. And we tend to learn very well by taking a nine minute cycle.
Andrew Huberman22:38
Transitioning into some focus mode early in the cycle is hard to focus. And then deep focus and and learning feels almost like agitation and strain. And then by the end of that ninety minute cycle becomes very hard to maintain focus and learn more information.
Andrew Huberman22:54
There's a study publishing cell reports last year, great journal um excEllent paper showing that twenty minute maps or light sleep of the sort of non sleep deeper as taken immediately after where close to you doesn't have to be immediately after you finish the last sentence of learning or whatever IT is or or bar of music but you know a couple minutes after transitioning to a period of of non sleep deeper breath where you're turning off the analysis of duration path. An outcome has been shown to accelerate learning to a significant degree, both the amount of information and the retention of that information. So that's pretty cool because this is a um cost free, drug free way of accelerating learning without having to get more sleep.
Andrew Huberman23:40
But simply by introducing these twenty minutes about, I would encourage people, if they want to try this, to consider the twenty minutes per every ninety minutes of ultra and learning cycle, which brings us to the next thing about learning and plasticity, which is neutrogena A K A smart drugs. This is a big topic. That sigh was a sigh of concern about how to address new tropics in a throw, enough, but thoughtful all enough way.
Andrew Huberman24:08
There are elements to learning that we've discussed here before that are very concrete, things like the ability to focus and put the blinders on to everything else that's happening in around you and in your head mainly write distractions about things you should be doing, could be doing or might be doing and focus on what you need to do. And then that's required for trigger ing. That is, see to calling neuromodulator.
Andrew Huberman24:32
That will then allow you to highlight the particular synapse is that will then later change in sleep. So no new tropic allows you to bypass the need for sleep in the breast. That's important.
Andrew Huberman24:43
understand? Right now, most new tropics tend to bundle a bunch of things together. Most of them includes some form of stimulant, caffeine, just, just more stimulant to be more focused.
Andrew Huberman24:54
IT doesn't work that way. Most neutral pics also include things that increase, or a design to increase a, to calling things like off A G, P, C. And other things of that sort.
Andrew Huberman25:05
And indeed, there are some evidence that they can increase a seto calling. So we need the focus component. We need the alertness component. The alertness component comes from happeneth, traditionally from caffeine stimulation. The aca calling stimulation traditionally comes from calling donors or alpha.
Andrew Huberman25:20
Gpc thinks that sort and then you would want to have some sort of off switch because anything that's gonna stimulate your alertness that then provides a crash. That crash is not a crash into the deep kind of wrestle slumber that you would want for learning. It's a crash into the kind of, let's just call, IT lopsided sleep, meaning it's deep sleep.
Andrew Huberman25:43
But IT lacks certain spindles and other elements of the physiology sleep spindles that that really engaged the learning process and the reconfiguration of synapses. So right now my stands on new tropics is that maybe maybe for occasional use for provided IT safe for you? I'm not recommending IT, but in general, IT tends to use more of a shotgun approach that is probably gonna useful for learning and memory in the long run.
Andrew Huberman26:15
okay. I'd like to continue by talking about the role of temperature in sleep, accessing sleep, staying asleep and wakeful. This temperature is super interesting as IT relates to circadian rythm and wakefulness and sleep.
Andrew Huberman26:30
First, let's take a look at what's happening to our body temperature across each twenty four hour cycle. In general, our temperature tends to be lowest to write around four A M and starts creeping up around six am A A M and peaks sometime between four pm and six pm. There is also an important way in which temperature matches daylight.
Andrew Huberman26:55
In general, as days get longer, IT tends to be hot out, not always, but in general, that's the way IT is. And as days get shorter, IT tends to be colder outside. So temperature and daily are also linked.
Andrew Huberman27:07
Meta ics, they're linked biologically, they are linked, excuse me, and atmospheric, they're linked for the reason that we talked about before about duration of daylight, th and other climate features and so forth. So one of the most powerful things about setting your skating rythm properly is that your temperature will start to fall into a regular rythm. And that temperature has a very strong effect on things like meta lisp.
Andrew Huberman27:33
And when you will feel most willing and interested in exercising, typically the willingness to exercise and engage in any kind of activity, mental or physical, is going to be when that rise in temperature is steepest, when the slope of that line is greatest. That's why thirty minutes after waking is one of those key windows, as well as three hours after waking. And then when temperature actually peaks, which is generally, generally about eleven hours after waking.
Andrew Huberman28:00
So this is why we say that temperature and certaine rythm are linked, but they're actually even more linked than mp. We've talked before about how light enters the eye, triggers activation of these melon ops and cells, which then triggers activation of the super kids matic nucleus. The master cirta an clock.
Andrew Huberman28:17
And then I always say the master can clock forms all the cells and tissues of your body and puts them into a nice, coherent rythm. But what i've never answered was how IT actually puts them into that rythm. And IT does IT two ways.
Andrew Huberman28:30
One is its secrets of peptide. And peptide is just a little protein that floats through the bloodstream and signals to the cells. But the other way is that synchronised, the temperature under which those cells exist.
Andrew Huberman28:42
So temperature is actually the effector of the craton rythm nowaday. They're some interest in cold showers and ice bath. Getting into an ice bath is very interesting because you have a rebound increase in thermo genesis. Now you should know from the previous episode that as the temperature increases, IT will shift your circuit rythm in which direction that shifts are circling rhythm will depend on whether not you're doing IT during the day time. You're late in the day.
Andrew Huberman29:08
If you do IT after eight pm, it's going to make your day longer, right? Because your body and your central clock are used to temperature going up early in the day and throughout the day and peaking in the afternoon. If you then increase that further, or you simply increase IT over its baseline at eight P M after temperature is already following, even if just by a half a degree or a couple degrees, or you do that with exercise, doesn't have to be with the ice path you are extending, you are shifting forward, you are face delaying your clock.
Andrew Huberman29:39
You're convincing your clock, and therefore the rest of your body that the day is still going right. You're giving at the perception, the cellar and psychological perception that the day is getting longer and you will want to naturally stay up later and wake up later. So for those of you that are having trouble getting up, and this is going to almost unlaid hable, but a cold shower, first thing in the morning wake you up, but that's waking you up in the short term because of a different mechanism, which i'll talk about a moment.
Andrew Huberman30:06
But IT also is shifting your clock. It's face advancing your clock in a way that makes you more likely to get up earlier the next day. It's going to make you want to wake up about half hour to an hour earlier the next day, then you Normally would whether if you do IT while your temperature is falling, IT will tend to delay and make your body perceive as if the day is getting longer.
Andrew Huberman30:28
But temperature is, again, is not just one tool to manipulate wake up time in circuiting rhythm and metabolic IT is the effector IT is the way that the central circadian in clock impacts all the cells and tissues of your body. Light is the trigger. The super kids matic nucleus is the masters circling clock that mediates.
Andrew Huberman30:47
All these changes also influences by non photic influence, like exercise and feeding and things that sort. But temperature is the effector. Now you can also shift your skating rythm with eating when you travel and you land in a new location.
Andrew Huberman31:02
And your schedule is inverted twelve hours. One way that we know you can shift your rythm more quickly is to get onto the local meal schedule. Now that probably has to do with two effects.
Andrew Huberman31:12
Warner, changes in temperature and eating induced increases in body temperature. Now you should understand why that would work, as well as eating has a anticipatory secretion of hyper create erection that I talked about IT earlier. I'd like to take a quick break and think one of our sponsors, David.
Andrew Huberman31:28
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Andrew Huberman31:41
These bars from David also taste e amazing. My favorite flavor is chocolate chip cookie do. But then again, I also liked the chocolate fudge flavoured one, and I also like the cake lavoro one.
Andrew Huberman31:50
Basically, I like all the flavors. They're incredibly delicious for me. Personally, I striving mostly whole food. However, when i'm in a rush or i'm away from home, or i'm just looking for a quick afternoon snack, I often find that i'm looking for a high quality protein source.
Andrew Huberman32:04
With David, i'm able to get twenty eight grim of protein with the calories of a snack, which makes IT very easy to hit my protein goals of one grammar protein per pound of body way each day. And IT allows me to do that without taking in excess calories. I typically eat a David bar in the early afternoon, or even mid the afternoon if I want to bridge that gap between lunch and dinner.
Andrew Huberman32:23
I like that. It's a little bit sweet, so IT tastes like a tasty snack, but it's also given me that twenty agram of very high quality protein with just one hundred and fifty calories. If you would like to try David, you can go to David protein dotcom slash huberman again.
Andrew Huberman32:36
The link is David protein dot com slash huberman. Many people asked questions about food and neurotransmitters and how those relate to sleep wakefulness and mood, which is essentially twenty five hours of content for me to cover. But i'm going to trying to steal out the most common questions.
Andrew Huberman32:56
We've talked a lot about neuromodulators like top of minnesotan calling in north and efron. He may notice in those discussions that the precursors to say certa in is trip to fan. Trip to fan actually comes from the diet.
Andrew Huberman33:10
IT comes from the foods that we eat. Tyring is the precise to dope. IT comes from the foods that we eat and then want to be adjust them.
Andrew Huberman33:21
The those compounds are circulate to a variety of different cells and tissues. But IT is true that are food. And the partaken lor food is we can influence things like nea modulator levels to some extent.
Andrew Huberman33:34
Nuts in meat, in particular red meat, tend to be rich in things like tyring, right? That tells you right there that because tyring is the precursor doped and dopamine is the precursor an f an and ean afra, that those foods tend to end themselves toward the production of dopamine and epa on and the sorts of things that are associated with wakefulness. Now of course, the volume of food that we eat also impacts are wakefulness.
Andrew Huberman34:03
And we need a lot of anything, whether not its rebuy stakes, rice or cardboard. Please don't need cardboard. Your stomach of its very distended will draw a lot of blood into your gut, and you will divert blood from other tissues and you'll become sleepy.
Andrew Huberman34:17
So it's not just about food content, is also about food volume, right? Fasting states generally are associated with more alertness up an f and so forth, and fed states are generally associated with more quiescence and relaxation serotonin and and that kind of things that lend themselves more towards sleep and less towards alertness. And fed states are generally associated with more quiescence and relaxation, serotonin and and kind of things that lend themselves more towards sleep and less ward alertness.
Andrew Huberman34:51
There are a couple effects of food that are independent. Where is a couple effects of eating? Because the food will do IT when IT sitting across the but of eating that are powerful for modulating satan rythm wakeful ness sea.
Andrew Huberman35:06
And that's because every time we eat, we get eating, induce thermo genesis regardless of what we eat. And now you know from the discussion about temperature that if you're eating early in the day, you're tending to shift your rythm earlier so that you want to wake up earlier the next day. If you're eating very late in the day, even if you can fall asleep after that, there's a tendency for you to want to sleep later the next day.
Andrew Huberman35:28
So as we finish up, I just want to offer you the opportunity to do an experiment IT might be interesting. Just a suggestion to write down for each day when you went outside to get sunlight and when you did that relative to wakings. And then you might just take note of when you exercised and you might note when you might have felt chilled or cold, if you do, or you might felt particularly hot, or if you woke up in the midnight when you felt particularly hot.
Andrew Huberman35:58
And then the last thing you might want to do is just write down, if in when you did a non sleep depressed protocol, n sdr protocol, anything that your using to deliberately teach your nervous system how to go from more letters to more calmness in the waking state. By doing this, you can start to reveal some really interesting patterns. It's really about taking the patterns of behaviors of waking and light viewing and eating and exercise and super imposing that on what you're learning in this podcast and elsewhere, of course, and what you already know and trying to see where certain problem or problems or pain points might be arising.
Andrew Huberman36:36
Maybe you start to find that using cold exposure early in the day is great for you, but using IT late, if it's too late in the day, that's not great. Or if you're into the sona, even like some people, including myself, if I take a hot showers in in a hot top of sona late at night, well, then I get a compensate decrease in body tempered, and I sleep great, provided I hydrate well enough, because that can be kind of a dehydrates ating to sit and hot conditions. But if I do the song early in the day, unless I exercise immediately afterward, then I tend to get the temperature drop, which makes sense because we get the sona, you get via isolation, you throw off a lot of heat and then you generally get a compound or drop in temperature.
Andrew Huberman37:16
If you do that early in the day, that's right about the time that that temperatures trying to entrain the circling clocks of your body. So I just encourage you to start becoming scientists of your own physiology, of your own brain and body, and seeing how the various tools that you may may not be using are affecting your patterns of sleep, your patterns of attention and wakefulness. It's vitally important that if you do this, that you know that it's not about trying to get into an an extremely rigid schedule.
Andrew Huberman37:46
It's really about trying to identify variables that are most powerful for you and that push you in the direction that you want to go and changing the variables that are pushing your body and your mind in the director that you don't want to go. Self experimenting is something that should be done slowly, carefully. You don't want to be reckless about this.
Andrew Huberman38:04
And this is where I would say, manipulating one or two variables at a time is really going to be best, as opposed to changing know a dozen things. All that wants to really identify what is is that most powerful for you. And above all, thank you for your interest in science.
Edit:2024.12.24